Rapamycin

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Rapamycin (Sirolimus; AY 22989) [CAS 53123-88-9]

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产品详情

Cat. No.：	C100081	Chinese Name：	雷帕霉素
CAS：	53123-88-9	Formula：	C51H79NO13
MWt：	914.17	Purity：	>98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years 4°C 2 years
Research Area：	Cancer	Target：	IC50: 0.1 nM (mTOR)[1]
Description：	Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM. Rapamycin is also a potent autophagy activator.

[‍1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401.

[‍2]. Lalic H, et al. Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leuk Lymphoma. 2012 Nov;53(11):2253-61.

[‍3]. Takeuchi H, et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res, 2005, 65(8), 3336-3346.

[‍4]. Bodine SC, et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol, 2001, 3(11), 1014-1019.

[‍5]. Marin TM, et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associatedPTPN11 mutation. J Clin Invest. 2011 Mar;121(3):1026-43.

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友情链接：NCBI 锐竞喀斯玛商城快递100

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