Dabrafenib Mesylate (GSK2118436 Mesylate;GSK 2118436B) [CAS 1195768-06-9]

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Cat. No.：	C100451	Chinese Name：	甲磺酸达拉非尼
CAS：	1195768-06-9	Formula：	C24H24F3N5O5S3
MWt：	615.67	Purity：	≥98%
Solubility：	DMSO	Storage：	4°C for 2 years (Keep sealed and desiccative)
Research Area：	Cancer	Target：	IC50: 0.6 nM (BRAFV600E), 5 nM (CRAF)[4]
Description：	Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor, and inhibits the kinase activity of B-RafV600Eand c-Raf with IC50 values of 0.6, and 5.0 nM, respectively.

[1]. Greger JG, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther, 2012, 11(4), 909-920.

[2]. Lee S, et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22.

[3]. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9.

[4]. Alexander M Menzies, et al. Dabrafenib and its potential for the treatment of metastatic melanoma. Drug Des Devel Ther. 2012; 6: 391–405.

[5]. Posobiec LM, et al. Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation. Birth Defects Res B Dev Reprod Toxicol. 2015 Dec;104(6):244-52.

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