Corin | HDAC Inhibitor

信号通路

Anti-infection
Arenavirus
Bacterial
CMV
Enterovirus
Filovirus
Fungal
HBV
HCV
HIV
HSV
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Parasite
Reverse Transcriptase
RSV
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PROTAC-linker Conjugate for PAC
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Apoptosis
FKBP
Bcl-2 Family
c-Myc
Caspase
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MDM-2/p53
PKD
RIP kinase
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Autophagy
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LRRK2
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ULK
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Antifolate
APC
ATM/ATR
Aurora Kinase
Casein Kinase
CDK
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CRISPR/Cas9
Deubiquitinase
DNA Alkylator/Crosslinker
DNA-PK
DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
G-quadruplex
Haspin Kinase
HDAC
HSP
IRE1
Kinesin
LIM Kinase (LIMK)
Microtubule/Tubulin
Mps1
Nucleoside Antimetabolite/Analog
p97
PAK
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PPAR
RAD51
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Wee1
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Mps1
Myosin
PAK
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AMPK
Aurora Kinase
DNA Methyltransferase
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HDAC
Histone Acetyltransferase
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Histone Methyltransferase
JAK
MicroRNA
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Protein Arginine Deiminase
TAM Receptor
Sirtuin
GPCR/G Protein
5-HT Receptor
Adenosine Receptor
Adenylate Cyclase
Adiponectin Receptor
Adrenergic Receptor
Angiotensin Receptor
Bombesin Receptor
Bradykinin Receptor
Cannabinoid Receptor
CaSR
CCR
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CRFR
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EBI2/GPR183
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GHSR
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GPCR19
GPR109A
GPR119
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GPR139
GPR40
GPR55
GPR84
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Imidazoline Receptor
Leukotriene Receptor
LPL Receptor
mAChR
MCHR1 (GPR24)
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Melatonin Receptor
mGluR
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STING
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iGluR
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nAChR
NKCC
P-glycoprotein
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Potassium Channel
Proton Pump
SGLT
Sodium Channel
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URAT1
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15-PGDH
5 alpha Reductase
5-Lipoxygenase
Acetyl-CoA Carboxylase
Acyltransferase
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Aldehyde Dehydrogenase (ALDH)
Aldose Reductase
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Aminopeptidase
Angiotensin-converting Enzyme (ACE)
Arginase
ATGL
ATP Citrate Lyase
Carbonic Anhydrase
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Cytochrome P450
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Dopamine β-hydroxylase
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HSP
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Mineralocorticoid Receptor
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NADPH Oxidase
Nampt
NEDD8-activating Enzyme
Neprilysin
PAI-1
PDHK
PGC-1α
Phosphatase
Phosphodiesterase (PDE)
Phospholipase
Procollagen C Proteinase
Proteasome
Pyruvate Kinase
RAR/RXR
Renin
ROR
Ser/Thr Protease
SGK
Stearoyl-CoA Desaturase (SCD)
Thrombin
Tryptophan Hydroxylase
Tyrosinase
Xanthine Oxidase
Glutaminase
Glutathione Peroxidase
Neuronal Signaling
5-HT Receptor
AChE
Adenosine Kinase
Amyloid-β
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GlyT
iGluR
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nAChR
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γ-secretase
NF-κB
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MALT1
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PI3K/Akt/mTOR
Akt
AMPK
ATM/ATR
DNA-PK
GSK-3
MELK
mTOR
PDK-1
PI3K
PI4K
PIKfyve
PTEN
PROTAC
E3 Ligase Ligand-Linker Conjugate
Ligand for E3 Ligase
PROTAC
PROTAC Linker
PROTAC-linker Conjugate for PAC
Ligand for Target Protein for PROTAC
SNIPER
Target Protein Ligand-Linker Conjugate
Protein Tyrosine Kinase/RTK
Ack1
ALK
Bcr-Abl
BMX Kinase
Btk
c-Fms
c-Kit
c-Met/HGFR
Discoidin Domain Receptor
DYRK
EGFR
Ephrin Receptor
FAK
FGFR
FLT3
IGF-1R
Insulin Receptor
IRAK
Itk
PDGFR
PKA
Pyk2
ROS
Src
Syk
TAM Receptor
Trk Receptor
VEGFR
RET
Stem Cell/Wnt
Casein Kinase
ERK
Gli
GSK-3
Hedgehog
Hippo (MST)
JAK
Notch
Oct3/4
PKA
Porcupine
ROCK
sFRP-1
Smo
STAT
TGF-beta/Smad
Wnt
YAP
β-catenin
γ-secretase
TGF-beta/Smad
PKC
ROCK
TGF-beta/Smad
TGF-β Receptor
Vitamin D Related
VD/VDR
Others
Androgen Receptor
Aromatase
Estrogen Receptor/ERR
Progesterone Receptor
Thyroid Hormone Receptor
Others
Inhibitory Antibodies
Cytokines
ADC
Epigenetic Reader Dom

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Corin [CAS 1808113-09-8]

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产品详情

Cat. No.：	C108174	CAS：	1808113-09-8
Formula：	C26H28N4O2	MWt：	428.53
Purity：	>98%	Solubility：	DMSO
Storage：	4°C, stored under nitrogen. In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)	Research Area：	Cancer
Target：	IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)	Description：	Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.

[1]. Kalin JH, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 Jan 4;9(1):53.

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