Cabozantinib S-malate (XL184 S-malate; BMS-907351 S-malate) [CAS 1140909-48-3]

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产品详情

Cat. No.：	C100217	Chinese Name：	卡博替尼苹果酸盐
CAS：	1140909-48-3	Formula：	C32H30FN3O10
MWt：	635.59	Purity：	≥98%
Solubility：	DMSO: ≥ 23 mg/mL	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cancer	Target：	IC50: 0.035 nM (VEGFR-2 (KDR)), 1.3 nM (c-Met), 4 nM (Ret), 4.6 nM (Kit), 12 nM (Flt-1), 11.3 nM (Flt-2), 6 nM (Flt-3), 14.3 nM (Tie2), 7 nM (AXL)
Description：	Cabozantinib S-malate is a potent VEGFR2 inhibitor with IC50 of 0.035 nM, and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM a

[1]. You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768.

[2]. Torres KE, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res, 2011, 17(12), 3943-3955.

[3]. Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308.

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