Talarozole (R115866) [CAS 201410-53-9] - ChemeGen-活性小分子-抑制剂-激动剂

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Talarozole (R115866) [CAS 201410-53-9]

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产品详情

Cat. No.：	C100441	Chinese Name：	他拉罗唑
CAS：	201410-53-9	Formula：	C21H23N5S
MWt：	377.51	Purity：	≥98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Target：	IC50: 0.46/5.1 nM (CYP26B1/A1)[1]	Description：	Talarozole is a potent inhibitor of both CYP26A1 and CYP26B1 with IC50 of 0.46 nM and 5.1 nM for CYP26B1 and CYP26A1, respectively.

[1]. Diaz P, et al. Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, theHuman Liver Retinoic Acid Hydroxylase. J Med Chem. 2016 Mar 24;59(6):2579-95.

[2]. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in theelimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.

[3]. Faith Stevison, et al. CYP26 Inhibition Increases Retinoic Acid Concentrations in Target Tissues and Alters Retinoid Signaling.

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