Osimertinib (AZD-9291)︱Selective Mutant EGFR 抑制剂︱ChemeGen

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Osimertinib (AZD-9291; Mereletinib;azd9291) [CAS 1421373-65-0]

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￥960.00~7480.00

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产品详情

Cat. No.：	C100602	Chinese Name：	奥斯替尼
CAS：	1421373-65-0	Formula：	C28H33N7O2
MWt：	499.61	Purity：	≥98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Target：	IC50: 1 nM (EGFRL858R/T790M), 12 nM (EGFRL858R)[1]	Description：	Osimertinib (AZD-9291) is an irreversible and mutant selective EGFR inhibitor with IC50 values of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively.

[1]. Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790Mmediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61.

[2]. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistancemutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

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