Tucidinostat (Chidamide;HBI-8000;CS 055) [CAS 1616493-44-7] - ChemeGen-活性小分子-抑制剂-激动剂

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Tucidinostat (Chidamide;HBI-8000;CS 055) [CAS 1616493-44-7]

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产品详情

Cat. No.：	C106053	Chinese Name：	西达本胺
CAS：	1616493-44-7	Formula：	C22H19FN4O2
MWt：	390.41	Purity：	>98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cancer	Target：	HDAC3：67 nM (IC50)
Description：	Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM,

[1]. Ning ZQ, et al. Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9.

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