HPOB [CAS 1429651-50-2] - ChemeGen-活性小分子-抑制剂-激动剂

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HPOB [CAS 1429651-50-2]

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产品详情

Cat. No.：	C105707	CAS：	1429651-50-2
Formula：	C17H18N2O4	MWt：	314.34
Purity：	>98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months; -20°C 1 month	Research Area：	Cancer
Target：	IC50: 0.056 μM (HDAC6), 1.7 μM (HDAC3/NCOR2), 2.8 μM (HDAC8), 2.9 μM (HDAC1), 3.0 μM (HDAC10), 4.4 μM (HDAC2)	Description：	HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.

[1]. Lee JH et al. Development of a histone deacetylase 6 inhibitor and its biological effects. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9.

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