(-)-PX20606 trans isomer ((-)-PX-102 trans isomer;(-)-PX-104) [CAS 1268244-88-7]

信号通路

Anti-infection
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PIKfyve
PTEN
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E3 Ligase Ligand-Linker Conjugate
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PROTAC Linker
PROTAC-linker Conjugate for PAC
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SNIPER
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Protein Tyrosine Kinase/RTK
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β-catenin
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TGF-β Receptor
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ADC
Epigenetic Reader Dom

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产品详情

Cat. No.：	C104459	CAS：	1268244-88-7
Formula：	C29H22Cl3NO4	MWt：	554.85
Purity：	>98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months; -20°C 1 month	Research Area：	Metabolic Disease
Target：	EC50: 18 nM (FXR in FRET assay), 29 nM (FXR in M1H assay)	Description：	(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.

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