Sodium 4-phenylbutyrate (4-Phenylbutyric acid sodium; 4-PBA sodium) [1716-12-7]

信号通路

Anti-infection
Arenavirus
Bacterial
CMV
Enterovirus
Filovirus
Fungal
HBV
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HIV
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PROTAC-linker Conjugate for PAC
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Apoptosis
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Bcl-2 Family
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MDM-2/p53
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Autophagy
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Antifolate
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ATM/ATR
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Checkpoint Kinase (Chk)
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Deubiquitinase
DNA Alkylator/Crosslinker
DNA-PK
DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
G-quadruplex
Haspin Kinase
HDAC
HSP
IRE1
Kinesin
LIM Kinase (LIMK)
Microtubule/Tubulin
Mps1
Nucleoside Antimetabolite/Analog
p97
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PARP
PERK
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PPAR
RAD51
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MCHR1 (GPR24)
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URAT1
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15-PGDH
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Angiotensin-converting Enzyme (ACE)
Arginase
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Isocitrate Dehydrogenase (IDH)
Lactate Dehydrogenase
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NADPH Oxidase
Nampt
NEDD8-activating Enzyme
Neprilysin
PAI-1
PDHK
PGC-1α
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Phospholipase
Procollagen C Proteinase
Proteasome
Pyruvate Kinase
RAR/RXR
Renin
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Stearoyl-CoA Desaturase (SCD)
Thrombin
Tryptophan Hydroxylase
Tyrosinase
Xanthine Oxidase
Glutaminase
Glutathione Peroxidase
Neuronal Signaling
5-HT Receptor
AChE
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Amyloid-β
Beta-secretase
CaMK
CGRP Receptor
COMT
Dopamine Receptor
Dopamine Transporter
FAAH
GABA Receptor
GlyT
iGluR
Imidazoline Receptor
mAChR
Melanocortin Receptor
Melatonin Receptor
Monoamine Oxidase
nAChR
Neurokinin Receptor
Opioid Receptor
Serotonin Transporter
γ-secretase
NF-κB
IKK
Keap1-Nrf2
MALT1
NF-κB
PI3K/Akt/mTOR
Akt
AMPK
ATM/ATR
DNA-PK
GSK-3
MELK
mTOR
PDK-1
PI3K
PI4K
PIKfyve
PTEN
PROTAC
E3 Ligase Ligand-Linker Conjugate
Ligand for E3 Ligase
PROTAC
PROTAC Linker
PROTAC-linker Conjugate for PAC
Ligand for Target Protein for PROTAC
SNIPER
Target Protein Ligand-Linker Conjugate
Protein Tyrosine Kinase/RTK
Ack1
ALK
Bcr-Abl
BMX Kinase
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c-Fms
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DYRK
EGFR
Ephrin Receptor
FAK
FGFR
FLT3
IGF-1R
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IRAK
Itk
PDGFR
PKA
Pyk2
ROS
Src
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TAM Receptor
Trk Receptor
VEGFR
RET
Stem Cell/Wnt
Casein Kinase
ERK
Gli
GSK-3
Hedgehog
Hippo (MST)
JAK
Notch
Oct3/4
PKA
Porcupine
ROCK
sFRP-1
Smo
STAT
TGF-beta/Smad
Wnt
YAP
β-catenin
γ-secretase
TGF-beta/Smad
PKC
ROCK
TGF-beta/Smad
TGF-β Receptor
Vitamin D Related
VD/VDR
Others
Androgen Receptor
Aromatase
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Progesterone Receptor
Thyroid Hormone Receptor
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Inhibitory Antibodies
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ADC
Epigenetic Reader Dom

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产品详情

Cat. No.：	C100570	Chinese Name：	苯丁酸钠
CAS：	1716-12-7	Formula：	C10H11NaO2
MWt：	186.18	Purity：	≥98%
Solubility：	H2O	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cancer/Infection	Target：	HDAC[1]
Description：	Sodium 4-phenylbutyrate is a histone deacetylase (HDAC) inhibitor, used in cancer and infection research.

[1]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferatoractivated receptorgamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12.

[2]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29.

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