Erlotinib Hydrochloride (CP-358774 HCl; NSC 718781 HCl; OSI-774 HCl) [CAS 183319-69-9]

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产品详情

Cat. No.：	C100203	Chinese Name：	盐酸埃罗替尼
CAS：	183319-69-9	Formula：	C22H24ClN3O4
MWt：	429.90	Purity：	≥98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Target：	IC50: 2 nM (EGFR)[1]	Description：	Erlotinib hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM.

[1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48.

[2]. Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719.

[3]. Marchetti S, et al. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.Mol Cancer Ther. 2008 Aug;7(8):2280-7.‍

[4]. Adachi K, et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14.

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