Cetuximab (C225)(Anti-Human EGFR) [CAS 205923-56-4] - ChemeGen-活性小分子-抑制剂-激动剂

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Cetuximab (C225)(Anti-Human EGFR) [CAS 205923-56-4]

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￥5600.00

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5 mg

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产品详情

Cat. No.：	CA10002	Chinese Name：	西妥昔单抗
CAS：	205923-56-4	MWt：	145543.35
Purity：	>98%	Research Area：	Cancer
Target：	EGFR:0.147 nM (Kd, Fixed A431 cells)	Description：	Cetuximab is a monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for soluble EGFR by SPR. Cetuximab has potent antitumor activity.

[1]. Goldstein NI, et al. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res. 1995 Nov;1(11):1311-8.

[2]. Gustafsson H, et al. EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model. Cell Biochem Biophys. 2017 Jul 29.

[3]. Huang SM, et al. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res. 1999 Apr 15;59(8):1935-40.

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