MSI-1436 lactate [CAS 1309370-86-2] - ChemeGen-活性小分子-抑制剂-激动剂

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MSI-1436 lactate [CAS 1309370-86-2]

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Cat. No.：	C103300	CAS：	1309370-86-2
Formula：	C37H72N4O5S⋅7/2C3H6O3	MWt：	1000.17
Purity：	≥95%	Solubility：	DMSO;H2O
Storage：	Powder -20°C 3 years; 4°C 2 years	Research Area：	Endocrinology
Target：	IC50: 1 μM (PTB1B), 224 μM (TCPTP)[1]	Description：	MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).

[1]. Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-1523.‍

[2]. Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31.‍

[3]. Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.

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