Dovitinib (TKI258; CHIR-258) [CAS 405169-16-6] - ChemeGen-活性小分子-抑制剂-激动剂

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Dovitinib (TKI258; CHIR-258) [CAS 405169-16-6]

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产品详情

Cat. No.：	C100850	Chinese Name：	多韦替尼
CAS：	405169-16-6	Formula：	C21H21FN6O
MWt：	392.43	Purity：	≥98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cancer	Target：	IC50: 5 nM (FGFR3)
Description：	Dovitinib is a multitargeted RTK inhibitor, and inhibits FGFR3 with IC50 of 5 nM.

[1]. Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005, 105(7), 2941-2948.‍

[2]. Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56(3), 595-601.

[3]. Lee Y, et al. A Receptor Tyrosine Kinase Inhibitor, Dovitinib (TKI-258), Enhances BMP-2-Induced Osteoblast Differentiation In Vitro. Mol Cells. 2016 May 31;39(5):389-94‍

[4]. Chon HJ, et al. Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells. Amino Acids. 2016 Jul;48(7):1591-9.

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