(R)-Baclofen (STX209) [CAS 69308-37-8] - ChemeGen-活性小分子-抑制剂-激动剂

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(R)-Baclofen (STX209) [CAS 69308-37-8]

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产品详情

Cat. No.：	C102895	Chinese Name：	(R)-巴氯芬
CAS：	69308-37-8	Formula：	C10H12ClNO2
MWt：	213.66	Purity：	>98%
Solubility：	H2O	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Neurological Disease	Description：	(R)-Baclofen (STX209) is a selective GABAB receptor agonist.

[1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903.‍

[2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75.‍

[3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9.‍

[4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14.

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