Aliskiren (CGP 60536; CGP60536B; SPP 100) [CAS 173334-57-1] - ChemeGen-活性小分子-抑制剂-激动剂

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Anti-infection
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Aliskiren (CGP 60536; CGP60536B; SPP 100) [CAS 173334-57-1]

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产品详情

Cat. No.：	C102550	Chinese Name：	阿利吉仑
CAS：	173334-57-1	Formula：	C30H53N3O6
MWt：	551.76	Purity：	>98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cardiovascular Disease	Target：	IC50 value: 1.5 nM [1] Target: renin
Description：	Aliskiren (CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.

[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758‍

[2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31.‍

[3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705.

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