Sufugolix (TAK-013) [CAS 308831-61-0] - ChemeGen-活性小分子-抑制剂-激动剂

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Anti-infection
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Sufugolix (TAK-013) [CAS 308831-61-0]

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产品详情

Cat. No.：	C102400	CAS：	308831-61-0
Formula：	C36H31F2N5O4S	MWt：	667.72
Purity：	>98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month	Research Area：	Endocrinology
Target：	IC50: 0.1 nM (human LHRH), 0.6 nM (monkey LHRH)[1]	Description：	Sufugolix (TAK-013) is a highly potent and orally available luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.1 nM.

[1]. Sasaki S, et al. Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor. J Med Chem. 2003 Jan 2;46(1):113-24.

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