Acetazolamide [CAS 59-66-5] - ChemeGen-活性小分子-抑制剂-激动剂

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Acetazolamide [CAS 59-66-5]

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Cat. No.：	C102339	Chinese Name：	乙酰唑胺
CAS：	59-66-5	Formula：	C4H6N4O3S2
MWt：	222.25	Purity：	>98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cardiovascular Disease	Description：	Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX[1]. Diuretic effects[4].

1. Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10.‍

2. Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306.‍

3. Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156.‍

4. Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8.

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