Mifepristone | Progesterone Receptor Antagonist

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Mifepristone (RU486;RU 38486) [CAS 84371-65-3]

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产品详情

Cat. No.：	C101465	Chinese Name：	美服培酮
CAS：	84371-65-3	Formula：	C29H35NO2
MWt：	429.59	Purity：	>98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Endocrinology	Target：	IC50: 0.2 nM (Progesterone Receptor, T47D cell), 2.6 nM (Glucocorticoid Receptor, A549 cell)[1]
Description：	Mifepristone (RU486) is an antagonist of progesterone receptor (PR) and glucocorticoid receptor (GR), with IC50 values of 0.2 nM and 2.6 nM, respectively, in cell assay.

[1]. Jiang W, et al. New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids. Bioorg Med Chem. 2006 Oct 1;14(19):6726-32.‍

[2]. Jurado R, et al. Cisplatin cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study. Oncol Rep. 2009 Nov;22(5):1237-45.‍

[3]. Sharrett-Field L, et al. Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo. Alcohol Clin Exp Res. 2013 Aug;37(8):1417-23.

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