ML224 (NCGC00242364;ANTAG3) [CAS 1338824-21-7] - ChemeGen-活性小分子-抑制剂-激动剂

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Anti-infection
Arenavirus
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CMV
Enterovirus
Filovirus
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Parasite
Reverse Transcriptase
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FKBP
Bcl-2 Family
c-Myc
Caspase
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MDM-2/p53
PKD
RIP kinase
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LRRK2
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Antifolate
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DNA Alkylator/Crosslinker
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DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
G-quadruplex
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HDAC
HSP
IRE1
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p97
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Adenosine Receptor
Adenylate Cyclase
Adiponectin Receptor
Adrenergic Receptor
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Bombesin Receptor
Bradykinin Receptor
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EBI2/GPR183
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GPCR19
GPR109A
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GPR55
GPR84
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Leukotriene Receptor
LPL Receptor
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MCHR1 (GPR24)
Melanocortin Receptor
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mGluR
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URAT1
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15-PGDH
5 alpha Reductase
5-Lipoxygenase
Acetyl-CoA Carboxylase
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Aldehyde Dehydrogenase (ALDH)
Aldose Reductase
Aminoacyl-tRNA Synthetase
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Angiotensin-converting Enzyme (ACE)
Arginase
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Cytochrome P450
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HCV Protease
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HSP
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NADPH Oxidase
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NEDD8-activating Enzyme
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PGC-1α
Phosphatase
Phosphodiesterase (PDE)
Phospholipase
Procollagen C Proteinase
Proteasome
Pyruvate Kinase
RAR/RXR
Renin
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Ser/Thr Protease
SGK
Stearoyl-CoA Desaturase (SCD)
Thrombin
Tryptophan Hydroxylase
Tyrosinase
Xanthine Oxidase
Glutaminase
Glutathione Peroxidase
Neuronal Signaling
5-HT Receptor
AChE
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Amyloid-β
Beta-secretase
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CGRP Receptor
COMT
Dopamine Receptor
Dopamine Transporter
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GlyT
iGluR
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Monoamine Oxidase
nAChR
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γ-secretase
NF-κB
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Akt
AMPK
ATM/ATR
DNA-PK
GSK-3
MELK
mTOR
PDK-1
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PI4K
PIKfyve
PTEN
PROTAC
E3 Ligase Ligand-Linker Conjugate
Ligand for E3 Ligase
PROTAC
PROTAC Linker
PROTAC-linker Conjugate for PAC
Ligand for Target Protein for PROTAC
SNIPER
Target Protein Ligand-Linker Conjugate
Protein Tyrosine Kinase/RTK
Ack1
ALK
Bcr-Abl
BMX Kinase
Btk
c-Fms
c-Kit
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IGF-1R
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IRAK
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PDGFR
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VEGFR
RET
Stem Cell/Wnt
Casein Kinase
ERK
Gli
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Hippo (MST)
JAK
Notch
Oct3/4
PKA
Porcupine
ROCK
sFRP-1
Smo
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TGF-beta/Smad
Wnt
YAP
β-catenin
γ-secretase
TGF-beta/Smad
PKC
ROCK
TGF-beta/Smad
TGF-β Receptor
Vitamin D Related
VD/VDR
Others
Androgen Receptor
Aromatase
Estrogen Receptor/ERR
Progesterone Receptor
Thyroid Hormone Receptor
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Inhibitory Antibodies
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ADC
Epigenetic Reader Dom

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ML224 (NCGC00242364;ANTAG3) [CAS 1338824-21-7]

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产品详情

Cat. No.：	C101261	CAS：	1338824-21-7
Formula：	C31H31N3O5	MWt：	525.59
Purity：	>98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month	Research Area：	Endocrinology
Description：	ML224 (NCGC00242364) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM.

[1]. Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program‍

[2]. Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.

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