信号通路
  • Anti-infection
    Arenavirus
    Bacterial
    CMV
    Enterovirus
    Filovirus
    Fungal
    HBV
    HCV
    HIV
    HSV
    Influenza Virus
    Parasite
    Reverse Transcriptase
    RSV
    SARS-CoV
    Virus Protease
  • Antibody-drug Conjugate/ADC Related
    ADC Cytotoxin
    ADC Linker
    Drug-Linker Conjugates for ADC
    PROTAC-linker Conjugate for PAC
  • Apoptosis
    Apoptosis
    FKBP
    Bcl-2 Family
    c-Myc
    Caspase
    DAPK
    Ferroptosis
    IAP
    MDM-2/p53
    PKD
    RIP kinase
    Survivin
    Thymidylate Synthase
    TNF Receptor
  • Autophagy
    Autophagy
    LRRK2
    Mitophagy
    ULK
  • Cell Cycle/DNA Damage
    Antifolate
    APC
    ATM/ATR
    Aurora Kinase
    Casein Kinase
    CDK
    Checkpoint Kinase (Chk)
    CRISPR/Cas9
    Deubiquitinase
    DNA Alkylator/Crosslinker
    DNA-PK
    DNA/RNA Synthesis
    Eukaryotic Initiation Factor (eIF)
    G-quadruplex
    Haspin Kinase
    HDAC
    HSP
    IRE1
    Kinesin
    LIM Kinase (LIMK)
    Microtubule/Tubulin
    Mps1
    Nucleoside Antimetabolite/Analog
    p97
    PAK
    PARP
    PERK
    Polo-like Kinase (PLK)
    PPAR
    RAD51
    ROCK
    Sirtuin
    SRPK
    Telomerase
    TOPK
    Topoisomerase
    Wee1
  • Cytoskeleton
    Arp2/3 Complex
    Dynamin
    Gap Junction Protein
    Integrin
    Kinesin
    Microtubule/Tubulin
    Mps1
    Myosin
    PAK
  • Epigenetics
    AMPK
    Aurora Kinase
    DNA Methyltransferase
    Epigenetic Reader Domain
    HDAC
    Histone Acetyltransferase
    Histone Demethylase
    Histone Methyltransferase
    JAK
    MicroRNA
    PARP
    PKC
    Protein Arginine Deiminase
    TAM Receptor
    Sirtuin
  • GPCR/G Protein
    5-HT Receptor
    Adenosine Receptor
    Adenylate Cyclase
    Adiponectin Receptor
    Adrenergic Receptor
    Angiotensin Receptor
    Bombesin Receptor
    Bradykinin Receptor
    Cannabinoid Receptor
    CaSR
    CCR
    CGRP Receptor
    Cholecystokinin Receptor
    CRFR
    CXCR
    Dopamine Receptor
    EBI2/GPR183
    Endothelin Receptor
    GHSR
    Glucagon Receptor
    Glucocorticoid Receptor
    GNRH Receptor
    GPCR19
    GPR109A
    GPR119
    GPR120
    GPR139
    GPR40
    GPR55
    GPR84
    Guanylate Cyclase
    Histamine Receptor
    Imidazoline Receptor
    Leukotriene Receptor
    LPL Receptor
    mAChR
    MCHR1 (GPR24)
    Melanocortin Receptor
    Melatonin Receptor
    mGluR
    Motilin Receptor
    Neurokinin Receptor
    Neuropeptide Y Receptor
    Neurotensin Receptor
    Opioid Receptor
    Orexin Receptor (OX Receptor)
    Oxytocin Receptor
    P2Y Receptor
    Prostaglandin Receptor
    Protease-Activated Receptor (PAR)
    Ras
    RGS Protein
    Sigma Receptor
    Somatostatin Receptor
    TSH Receptor
    Urotensin Receptor
    Vasopressin Receptor
  • Immunology/Inflammation
    Arginase
    Aryl Hydrocarbon Receptor
    CCR
    Complement System
    COX
    CXCR
    FLAP
    Histamine Receptor
    IFNAR
    Interleukin Related
    IRAK
    MyD88
    NO Synthase
    NOD-like Receptor (NLR)
    PD-1/PD-L1
    PGE synthase
    Salt-inducible Kinase (SIK)
    SPHK
    STING
    Thrombopoietin Receptor
    Toll-like Receptor (TLR)
    CD73
    Reactive Oxygen Species
  • JAK/STAT Signaling
    EGFR
    JAK
    Pim
    STAT
  • MAPK/ERK Pathway
    ERK
    JNK
    KLF
    MAP3K
    MAP4K
    MAPKAPK2 (MK2)
    MEK
    Mixed Lineage Kinase
    MNK
    p38 MAPK
    Raf
    Ribosomal S6 Kinase (RSK)
  • Membrane Transporter/Ion Channel
    ATP Synthase
    BCRP
    Calcium Channel
    CFTR
    Chloride Channel
    CRAC Channel
    CRM1
    EAAT2
    GABA Receptor
    GlyT
    HCN Channel
    iGluR
    Monoamine Transporter
    Monocarboxylate Transporter
    Na+/Ca2+ Exchanger
    Na+/HCO3- Cotransporter
    Na+/K+ ATPase
    nAChR
    NKCC
    P-glycoprotein
    P2X Receptor
    Potassium Channel
    Proton Pump
    SGLT
    Sodium Channel
    TRP Channel
    URAT1
  • Metabolic Enzyme/Protease
    15-PGDH
    5 alpha Reductase
    5-Lipoxygenase
    Acetyl-CoA Carboxylase
    Acyltransferase
    Adenosine Deaminase
    Adenosine Kinase
    Aldehyde Dehydrogenase (ALDH)
    Aldose Reductase
    Aminoacyl-tRNA Synthetase
    Aminopeptidase
    Angiotensin-converting Enzyme (ACE)
    Arginase
    ATGL
    ATP Citrate Lyase
    Carbonic Anhydrase
    Carboxypeptidase
    Cathepsin
    CETP
    COMT
    Cytochrome P450
    Dipeptidyl Peptidase
    Dopamine β-hydroxylase
    Drug Metabolite
    E1/E2/E3 Enzyme
    Elastase
    Endogenous Metabolite
    Enolase
    FAAH
    FABP
    Factor Xa
    Farnesyl Transferase
    Fatty Acid Synthase (FAS)
    FXR
    Glucokinase
    GSNOR
    Gutathione S-transferase
    HCV Protease
    Hexokinase
    HIF/HIF Prolyl-Hydroxylase
    HIV Integrase
    HIV Protease
    HMG-CoA Reductase (HMGCR)
    HSP
    Indoleamine 2,3-Dioxygenase (IDO)
    Isocitrate Dehydrogenase (IDH)
    Lactate Dehydrogenase
    LXR
    MAGL
    Mineralocorticoid Receptor
    Mitochondrial Metabolism
    MMP
    NADPH Oxidase
    Nampt
    NEDD8-activating Enzyme
    Neprilysin
    PAI-1
    PDHK
    PGC-1α
    Phosphatase
    Phosphodiesterase (PDE)
    Phospholipase
    Procollagen C Proteinase
    Proteasome
    Pyruvate Kinase
    RAR/RXR
    Renin
    ROR
    Ser/Thr Protease
    SGK
    Stearoyl-CoA Desaturase (SCD)
    Thrombin
    Tryptophan Hydroxylase
    Tyrosinase
    Xanthine Oxidase
  • Neuronal Signaling
    5-HT Receptor
    AChE
    Adenosine Kinase
    Amyloid-β
    Beta-secretase
    CaMK
    CGRP Receptor
    COMT
    Dopamine Receptor
    Dopamine Transporter
    FAAH
    GABA Receptor
    GlyT
    iGluR
    Imidazoline Receptor
    mAChR
    Melanocortin Receptor
    Melatonin Receptor
    Monoamine Oxidase
    nAChR
    Neurokinin Receptor
    Opioid Receptor
    Serotonin Transporter
    γ-secretase
  • NF-κB
    IKK
    Keap1-Nrf2
    MALT1
    NF-κB
  • PI3K/Akt/mTOR
    Akt
    AMPK
    ATM/ATR
    DNA-PK
    GSK-3
    MELK
    mTOR
    PDK-1
    PI3K
    PI4K
    PIKfyve
    PTEN
  • PROTAC
    E3 Ligase Ligand-Linker Conjugate
    Ligand for E3 Ligase
    PROTAC
    PROTAC Linker
    PROTAC-linker Conjugate for PAC
    Ligand for Target Protein for PROTAC
  • Protein Tyrosine Kinase/RTK
    Ack1
    ALK
    Bcr-Abl
    BMX Kinase
    Btk
    c-Fms
    c-Kit
    c-Met/HGFR
    Discoidin Domain Receptor
    DYRK
    EGFR
    Ephrin Receptor
    FAK
    FGFR
    FLT3
    IGF-1R
    Insulin Receptor
    IRAK
    Itk
    PDGFR
    PKA
    Pyk2
    ROS
    Src
    Syk
    TAM Receptor
    Trk Receptor
    VEGFR
    RET
  • Stem Cell/Wnt
    Casein Kinase
    ERK
    Gli
    GSK-3
    Hedgehog
    Hippo (MST)
    JAK
    Notch
    Oct3/4
    PKA
    Porcupine
    ROCK
    sFRP-1
    Smo
    STAT
    TGF-beta/Smad
    Wnt
    YAP
    β-catenin
    γ-secretase
  • TGF-beta/Smad
    PKC
    ROCK
    TGF-beta/Smad
    TGF-β Receptor
  • Vitamin D Related
    VD/VDR
  • Others
    Androgen Receptor
    Aromatase
    Estrogen Receptor/ERR
    Progesterone Receptor
    Thyroid Hormone Receptor
    Others
  • Inhibitory Antibodies
  • Cytokines
  • ADC
  • Epigenetic Reader Dom
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定制及服务

产品定制

ChemeGen 拥有先进的生产设备、专业的研发技术和丰富的生产经验,能够合成从毫克到公斤级不等具有生物活性的化合物。我们可为客户提供如下定制服务:未经报道的化合物定制、已有化合物的放大生产及先导化合物的化学修饰,使之得到进一步优化成为理想的药物。

ChemeGen 不仅拥有完善的产品质量控制体系,还为客户提供优质的服务,把产品质量作为第一要素,不断加强技术革新,凭借先进的仪器设备及丰富的分析经验,确保每批产品的质量都能达到客户的要求。ChemeGen 助力您的新药开发过程!


技术服务

1. 细胞生物学服务

原代细胞的分离培养鉴定、细胞转染(瞬时、稳定)、细胞划痕、TranswellMTTCCK-8)、Hoechst 染色、流式检测细胞周期、细胞凋亡;流式 ROS 及钙离子、克隆行程实验等等。

2. 免疫学技术服务

WBCO-IPEMSAELISA

3. 病理学技术服务

组织的包埋,普通及冰冻切片、HE 染色、免疫组化、免疫荧光、TRAP 染色、茜素红染色、油红O 染色、TUNEL 细胞凋亡、Giemsa 染色、尼氏染色、PAS 染色等。

4. 基因组学技术服务

RT-PCRReal-timePCR、载体构建、定点突变、染色质免疫共沉淀 (Chip)

5. 抑制剂相关服务

1)相关抑制剂(激活剂)不同细胞内浓度的筛选;

2)新药的实验筛选(体内、体外);

3)联合药物治疗的应用;

4)我们可以根据您的需要为您定制所购买抑制剂的相关实验。



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