(±)-Ibipinabant ((±)-SLV319; (±)-BMS6462) [CAS 362519-49-1] - ChemeGen-活性小分子-抑制剂-激动剂

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(±)-Ibipinabant ((±)-SLV319; (±)-BMS6462) [CAS 362519-49-1]

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Cat. No.：	C103800	CAS：	362519-49-1
Formula：	C23H20Cl2N4O2S	MWt：	487.40
Purity：	>98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month	Research Area：	Metabolic Disease
Description：	(±)-Ibipinabant is the racemate of SLV319. SLV319 is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.

[1]. Chorvat RJ, et al. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.‍

[2]. Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem. 2004 Jan 29;47(3):627-43.

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