(-)-Indolactam V (Indolactam V) [CAS 90365-57-4] - ChemeGen-活性小分子-抑制剂-激动剂

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(-)-Indolactam V (Indolactam V) [CAS 90365-57-4]

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￥7790.00

Size：

5 mg

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产品详情

Cat. No.：	C100251	Chinese Name：	吲哚内酰胺 V
CAS：	90365-57-4	Formula：	C17H23N3O2
MWt：	301.38	Purity：	≥98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cancer	Target：	Ki: 3.36 nM (η-CRD2 (PKCη surrogate peptide)), 1.03 μM (γ-CRD2 (PKCγ surrogate peptide))[1]Kd: 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1
Description：	(-)-Indolactam V is a PKC activator, with Ki of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kd of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM

[1]. Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61(8):1415-7.

[2]. Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7.‍

[3]. Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5(4):258-65.

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