Vorinostat (SAHA) [CAS 149647-78-9] - ChemeGen-活性小分子-抑制剂-激动剂

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Anti-infection
Arenavirus
Bacterial
CMV
Enterovirus
Filovirus
Fungal
HBV
HCV
HIV
HSV
Influenza Virus
Parasite
Reverse Transcriptase
RSV
SARS-CoV
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ADC Cytotoxin
ADC Linker
Drug-Linker Conjugates for ADC
PROTAC-linker Conjugate for PAC
Apoptosis
Apoptosis
FKBP
Bcl-2 Family
c-Myc
Caspase
DAPK
Ferroptosis
IAP
MDM-2/p53
PKD
RIP kinase
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Thymidylate Synthase
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Autophagy
Autophagy
LRRK2
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ULK
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Antifolate
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ATM/ATR
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Casein Kinase
CDK
Checkpoint Kinase (Chk)
CRISPR/Cas9
Deubiquitinase
DNA Alkylator/Crosslinker
DNA-PK
DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
G-quadruplex
Haspin Kinase
HDAC
HSP
IRE1
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Mps1
Nucleoside Antimetabolite/Analog
p97
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Adiponectin Receptor
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EBI2/GPR183
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GPCR19
GPR109A
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GPR139
GPR40
GPR55
GPR84
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MCHR1 (GPR24)
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mGluR
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URAT1
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15-PGDH
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5-Lipoxygenase
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Aldehyde Dehydrogenase (ALDH)
Aldose Reductase
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Angiotensin-converting Enzyme (ACE)
Arginase
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PAI-1
PDHK
PGC-1α
Phosphatase
Phosphodiesterase (PDE)
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Procollagen C Proteinase
Proteasome
Pyruvate Kinase
RAR/RXR
Renin
ROR
Ser/Thr Protease
SGK
Stearoyl-CoA Desaturase (SCD)
Thrombin
Tryptophan Hydroxylase
Tyrosinase
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Glutaminase
Glutathione Peroxidase
Neuronal Signaling
5-HT Receptor
AChE
Adenosine Kinase
Amyloid-β
Beta-secretase
CaMK
CGRP Receptor
COMT
Dopamine Receptor
Dopamine Transporter
FAAH
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GlyT
iGluR
Imidazoline Receptor
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Monoamine Oxidase
nAChR
Neurokinin Receptor
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γ-secretase
NF-κB
IKK
Keap1-Nrf2
MALT1
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PI3K/Akt/mTOR
Akt
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ATM/ATR
DNA-PK
GSK-3
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PDK-1
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PI4K
PIKfyve
PTEN
PROTAC
E3 Ligase Ligand-Linker Conjugate
Ligand for E3 Ligase
PROTAC
PROTAC Linker
PROTAC-linker Conjugate for PAC
Ligand for Target Protein for PROTAC
SNIPER
Target Protein Ligand-Linker Conjugate
Protein Tyrosine Kinase/RTK
Ack1
ALK
Bcr-Abl
BMX Kinase
Btk
c-Fms
c-Kit
c-Met/HGFR
Discoidin Domain Receptor
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EGFR
Ephrin Receptor
FAK
FGFR
FLT3
IGF-1R
Insulin Receptor
IRAK
Itk
PDGFR
PKA
Pyk2
ROS
Src
Syk
TAM Receptor
Trk Receptor
VEGFR
RET
Stem Cell/Wnt
Casein Kinase
ERK
Gli
GSK-3
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Hippo (MST)
JAK
Notch
Oct3/4
PKA
Porcupine
ROCK
sFRP-1
Smo
STAT
TGF-beta/Smad
Wnt
YAP
β-catenin
γ-secretase
TGF-beta/Smad
PKC
ROCK
TGF-beta/Smad
TGF-β Receptor
Vitamin D Related
VD/VDR
Others
Androgen Receptor
Aromatase
Estrogen Receptor/ERR
Progesterone Receptor
Thyroid Hormone Receptor
Others
Inhibitory Antibodies
Cytokines
ADC
Epigenetic Reader Dom

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Vorinostat (SAHA) [CAS 149647-78-9]

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Cat. No.：	C100082	Chinese Name：	伏瑞斯特
CAS：	149647-78-9	Formula：	C14H20N2O3
MWt：	264.32	Purity：	≥98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Research Area：	Cancer	Target：	ID50: 10 nM (HDAC1), 20 nM (HDAC3)[3]HDAC2, HDAC7[1], HDAC11[4]
Description：	Vorinostat is a potent and orally available inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and class IV (HDAC11), with ID50 values of 10 nM and 20 nM for HDAC1/3, respectively.

[‍1]. Hrzenjak A et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010 Mar 4;9:49.

[‍2]. Lautz TB, et al. The effect of vorinostat on the development of resistance to Doxorubicin in neuroblastoma.PLoS One. 2012;7(7):e40816.‍

[‍3]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.

[4]. Xu WS, et al. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007 Aug 13;26(37):5541-52.

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