Sorafenib (Bay 43-9006) [CAS 284461-73-0] - ChemeGen-活性小分子-抑制剂-激动剂

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Sorafenib (Bay 43-9006) [CAS 284461-73-0]

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产品详情

Cat. No.：	C100070	Chinese Name：	索拉非尼
CAS：	284461-73-0	Formula：	C21H16ClF3N4O3
MWt：	464.83	Purity：	≥98%
Solubility：	DMSO	Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month
Target：	IC50: 6 nM (Raf-1), 20 nM (VEGFR-3), 22 nM (BRAF), 57 nM (PDGFR-β), 58 nM (Flt3), 68 nM (c-KIT), 90 nM (VEGFR-2)[1]	Description：	Sorafenib is a potent multikinase inhibitor with IC50 of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

[‍1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

[‍2]. El-Ashmawy NE, et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16.

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