(S)-(-)-Bay-K-8644 [CAS 98625-26-4] - ChemeGen-活性小分子-抑制剂-激动剂

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(S)-(-)-Bay-K-8644 [CAS 98625-26-4]

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产品详情

Cat. No.：	C101630	CAS：	98625-26-4
Formula：	C16H15F3N2O4	MWt：	356.30
Purity：	>98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month	Research Area：	Cardiovascular Disease
Target：	EC50: 32 nM (IBa)[1]	Description：	(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).

[1]. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.

[2]. Mironov SL, et al. Ltype Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87.

[3]. Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S)Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602.

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