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PF-00446687 [CAS 862281-92-3]
PF-00446687 [CAS 862281-92-3]
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产品详情
Cat. No.： C108069 CAS： 862281-92-3
Formula： C28H36F2N2O2 MWt： 470.59
Purity： >98% Solubility： DMSO
Storage： Powder  -20°C 3 years; 4°C 2 years   In solvent  -80°C 6 months;-20°C 1 month Research Area： Endocrinology
Target： EC50: 12 ± 1 nM (MC4R) Description： PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12?±?1 nM. Pf-446687 is brain penetrant.

[1]. Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53(8):3183-97.
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