NVP-BSK805 dihydrochloride (BSK805 dihydrochlorid) [CAS 1942919-79-0] - ChemeGen-活性小分子-抑制剂-激动剂

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NVP-BSK805 dihydrochloride (BSK805 dihydrochlorid) [CAS 1942919-79-0]

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Cat. No.：	C100455	CAS：	1942919-79-0
Formula：	C₂₇H₃₀Cl₂F₂N₆O	MWt：	563.47
Purity：	≥98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months;-20°C 1 month	Research Area：	Cancer
Target：	IC50: 0.48 nM (JAK2 JH1), 31.63 nM (JAK1 JH1), 18.68 nM (JAK3 JH1), 10.76 nM (TYK2 JH1), 0.56 nM (FL JAK2 V617F), 0.58 nM (FL JAK2 wt)[1]	Description：	NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor, with IC50 of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

[1]. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55.

[2]. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182.

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