MG-132 (MG132; MG 132) [CAS 133407-82-6] - ChemeGen-活性小分子-抑制剂-激动剂

信号通路

Anti-infection
Arenavirus
Bacterial
CMV
Enterovirus
Filovirus
Fungal
HBV
HCV
HIV
HSV
Influenza Virus
Parasite
Reverse Transcriptase
RSV
SARS-CoV
Virus Protease
Antibody-drug Conjugate/ADC Related
ADC Cytotoxin
ADC Linker
Drug-Linker Conjugates for ADC
PROTAC-linker Conjugate for PAC
Apoptosis
Apoptosis
FKBP
Bcl-2 Family
c-Myc
Caspase
DAPK
Ferroptosis
IAP
MDM-2/p53
PKD
RIP kinase
Survivin
Thymidylate Synthase
TNF Receptor
Autophagy
Autophagy
LRRK2
Mitophagy
ULK
Cell Cycle/DNA Damage
Antifolate
APC
ATM/ATR
Aurora Kinase
Casein Kinase
CDK
Checkpoint Kinase (Chk)
CRISPR/Cas9
Deubiquitinase
DNA Alkylator/Crosslinker
DNA-PK
DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
G-quadruplex
Haspin Kinase
HDAC
HSP
IRE1
Kinesin
LIM Kinase (LIMK)
Microtubule/Tubulin
Mps1
Nucleoside Antimetabolite/Analog
p97
PAK
PARP
PERK
Polo-like Kinase (PLK)
PPAR
RAD51
ROCK
Sirtuin
SRPK
Telomerase
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Topoisomerase
Wee1
Cytoskeleton
Arp2/3 Complex
Dynamin
Gap Junction Protein
Integrin
Kinesin
Microtubule/Tubulin
Mps1
Myosin
PAK
Epigenetics
AMPK
Aurora Kinase
DNA Methyltransferase
Epigenetic Reader Domain
HDAC
Histone Acetyltransferase
Histone Demethylase
Histone Methyltransferase
JAK
MicroRNA
PARP
PKC
Protein Arginine Deiminase
TAM Receptor
Sirtuin
GPCR/G Protein
5-HT Receptor
Adenosine Receptor
Adenylate Cyclase
Adiponectin Receptor
Adrenergic Receptor
Angiotensin Receptor
Bombesin Receptor
Bradykinin Receptor
Cannabinoid Receptor
CaSR
CCR
CGRP Receptor
Cholecystokinin Receptor
CRFR
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Dopamine Receptor
EBI2/GPR183
Endothelin Receptor
GHSR
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GNRH Receptor
GPCR19
GPR109A
GPR119
GPR120
GPR139
GPR40
GPR55
GPR84
Guanylate Cyclase
Histamine Receptor
Imidazoline Receptor
Leukotriene Receptor
LPL Receptor
mAChR
MCHR1 (GPR24)
Melanocortin Receptor
Melatonin Receptor
mGluR
Motilin Receptor
Neurokinin Receptor
Neuropeptide Y Receptor
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Opioid Receptor
Orexin Receptor (OX Receptor)
Oxytocin Receptor
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Prostaglandin Receptor
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PD-1/PD-L1
PGE synthase
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STING
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EGFR
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iGluR
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Na+/HCO3- Cotransporter
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nAChR
NKCC
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Potassium Channel
Proton Pump
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TRP Channel
URAT1
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15-PGDH
5 alpha Reductase
5-Lipoxygenase
Acetyl-CoA Carboxylase
Acyltransferase
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Aldehyde Dehydrogenase (ALDH)
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Aminoacyl-tRNA Synthetase
Aminopeptidase
Angiotensin-converting Enzyme (ACE)
Arginase
ATGL
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Carboxypeptidase
Cathepsin
CETP
COMT
Cytochrome P450
Dipeptidyl Peptidase
Dopamine β-hydroxylase
Drug Metabolite
E1/E2/E3 Enzyme
Elastase
Endogenous Metabolite
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FAAH
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Factor Xa
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FXR
Glucokinase
GSNOR
Gutathione S-transferase
HCV Protease
Hexokinase
HIF/HIF Prolyl-Hydroxylase
HIV Integrase
HIV Protease
HMG-CoA Reductase (HMGCR)
HSP
Indoleamine 2,3-Dioxygenase (IDO)
Isocitrate Dehydrogenase (IDH)
Lactate Dehydrogenase
LXR
MAGL
Mineralocorticoid Receptor
Mitochondrial Metabolism
MMP
NADPH Oxidase
Nampt
NEDD8-activating Enzyme
Neprilysin
PAI-1
PDHK
PGC-1α
Phosphatase
Phosphodiesterase (PDE)
Phospholipase
Procollagen C Proteinase
Proteasome
Pyruvate Kinase
RAR/RXR
Renin
ROR
Ser/Thr Protease
SGK
Stearoyl-CoA Desaturase (SCD)
Thrombin
Tryptophan Hydroxylase
Tyrosinase
Xanthine Oxidase
Glutaminase
Glutathione Peroxidase
Neuronal Signaling
5-HT Receptor
AChE
Adenosine Kinase
Amyloid-β
Beta-secretase
CaMK
CGRP Receptor
COMT
Dopamine Receptor
Dopamine Transporter
FAAH
GABA Receptor
GlyT
iGluR
Imidazoline Receptor
mAChR
Melanocortin Receptor
Melatonin Receptor
Monoamine Oxidase
nAChR
Neurokinin Receptor
Opioid Receptor
Serotonin Transporter
γ-secretase
NF-κB
IKK
Keap1-Nrf2
MALT1
NF-κB
PI3K/Akt/mTOR
Akt
AMPK
ATM/ATR
DNA-PK
GSK-3
MELK
mTOR
PDK-1
PI3K
PI4K
PIKfyve
PTEN
PROTAC
E3 Ligase Ligand-Linker Conjugate
Ligand for E3 Ligase
PROTAC
PROTAC Linker
PROTAC-linker Conjugate for PAC
Ligand for Target Protein for PROTAC
SNIPER
Target Protein Ligand-Linker Conjugate
Protein Tyrosine Kinase/RTK
Ack1
ALK
Bcr-Abl
BMX Kinase
Btk
c-Fms
c-Kit
c-Met/HGFR
Discoidin Domain Receptor
DYRK
EGFR
Ephrin Receptor
FAK
FGFR
FLT3
IGF-1R
Insulin Receptor
IRAK
Itk
PDGFR
PKA
Pyk2
ROS
Src
Syk
TAM Receptor
Trk Receptor
VEGFR
RET
Stem Cell/Wnt
Casein Kinase
ERK
Gli
GSK-3
Hedgehog
Hippo (MST)
JAK
Notch
Oct3/4
PKA
Porcupine
ROCK
sFRP-1
Smo
STAT
TGF-beta/Smad
Wnt
YAP
β-catenin
γ-secretase
TGF-beta/Smad
PKC
ROCK
TGF-beta/Smad
TGF-β Receptor
Vitamin D Related
VD/VDR
Others
Androgen Receptor
Aromatase
Estrogen Receptor/ERR
Progesterone Receptor
Thyroid Hormone Receptor
Others
Inhibitory Antibodies
Cytokines
ADC
Epigenetic Reader Dom

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MG-132 (MG132; MG 132) [CAS 133407-82-6]

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产品详情

Cat. No.：	C100326	CAS：	133407-82-6
Formula：	C26H41N3O5	MWt：	475.62
Purity：	≥98%	Solubility：	DMSO
Storage：	4°C, protect from light. Freshly prepared is recommended.	Target：	IC50: 24.2 nM (chymotrypsin-like activity)[1]
Description：	MG-132 is a potent, non-specific 20S proteasome inhibitor, with IC50 of 24.2 nM for the β5 chymotrypsin-like active site.

[1]. Braun HA, et al. Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines. J Biol Chem. 2005 Aug 5;280(31):28394-401.

[2]. Han YH, et al. The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH. Oncol Rep. 2009 Jul;22(1):215-21.

[3]. Fan WH, et al. Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress. Acta Pharmacol Sin. 2011 May;32(5):619-25.

[4]. Matsumoto Y, et al. Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating theproteasome inhibitor MG132. Cancer Sci. 2016 Jun;107(6):773-81.

[5]. Chen B, et al. MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals. Acta Biochim Biophys Sin (Shanghai). 2010 Apr;42(4):253-8.

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