2R,4S-Sacubitril [CAS 761373-05-1] - ChemeGen-活性小分子-抑制剂-激动剂

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2R,4S-Sacubitril [CAS 761373-05-1]

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产品详情

Cat. No.：	C105791	CAS：	761373-05-1
Formula：	C24H29NO5	MWt：	411.49
Purity：	>98%	Solubility：	DMSO
Storage：	Powder -20°C 3 years; 4°C 2 years In solvent -80°C 6 months; -20°C 1 month	Research Area：	Cardiovascular Disease
Description：	2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

[1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.

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